Cherokee Reservoir, also known as Cherokee Lake, is a reservoir in Tennessee formed by the impoundment of the Holston River behind Cherokee Dam.
The reservoir has a surface area of about 28,780 acres (11,650 ha), a flood-storage capacity of 749,406 acre-feet, and nearly 400 miles (640 km) of shoreline. In a normal year, the lake water level fluctuates over a range of about 27 feet (8.2 m).